Rapid SARS-CoV-2 antigen detection potentiates early diagnosis of COVID-19 disease

As the COVID-19 epidemic is still ongoing, a more rapid detection of SARS-CoV-2 infection such as viral antigen-detection needs to be evaluated for early diagnosis disease. Here, we report dynamic changes antigens in nasopharyngeal swabs patients and its association with nucleic acid clearance clinical outcomes. Eighty-five were enrolled antigens, including 57 anti-SARS-CoV-2 antibody negative cases 28 positive cases. The antigen could detected 52.63% (30/57) at stage infection, especially first 5 days after disease onset (p = 0.0018) disappeared about 8 onset. Viral highly detectable low Ct value (less than 30) RT-PCT assay, suggesting expression was associated high load. Furthermore, indicated progression, nine (9/30, 30.0%), contrast two (2/27, 7.40%) 0.0444) antigen, which progressed into severe Thus, persistent stages when virus replicating status, promises rapidly screen infection.